Szeged, Hungary

Szeged sits on the Tisza River in southern Hungary, home to roughly 160,000 residents who rebuilt the city in Art Nouveau style after an 1879 flood destroyed 95% of its buildings. The twin-towered Votive Church, completed in 1930, anchors Dóm Square, the third-largest square in Hungary, where the Open-Air Festival has staged plays every summer since 1931. The Kalocsa–Szeged growing region supplies about 80% of the world's paprika, and at the 1872 University of Szeged, Albert Szent-Györgyi isolated vitamin C in 1931. That single discovery would later earn him a Nobel Prize.